Effectiveness of Nebulized Mild Hypertonic Saline Solution in Children with Mild-to-Moderate RSV Bronchiolitis: randomized, open-label intervention study (HYPERBRO)
STUDY DETAILS
Population: 110 infants aged 1-24 months with mild-to-moderate bronchiolitis visiting the ER Hospital Department.
Group 1: Infants receiving standard nebulized medication and nebulized
0.9% NaCl
Group 2: Infants receiving standard nebulized medication and nebulized
2.3% NaCl (Sinomarin Babies)
Length of intervention:
7 Days
Primary Objective:
- Compare percentage of patients in both groups that achieve a reduction of 50% in Wang clinical severity score at Day 3 versus baseline
PRELIMINARY RESULTS
Results from 42 patients (target population: 110 patients)
Positive results for primary objective:
Positive results for primary objective:
- The possibility of a positive outcome in achieving a reduction of 50% in clinical severity score (Wang), on Day 3 versus baseline, is 55% lower in saline group.
- Clinical severity score at 7 days: trend of a significantly better outcome in Sinomarin group (P=0.262) with significant improvement in both groups over time (P<0.001)
4th Children’s Health Congress; Croatian Society for Preventive & Social Paediatrics
